![]() ![]() Here we propose heuristics for manual baseline and phase correction to reduce this analyst-dependent error to about 3 %. Furthermore, a round robin study demonstrates that the second major source of uncertainty in these measurements arises from the manual processing of the spectra by different analysts. We confirm that for moderately dilute samples (less than 0.2 M), the integral area of the solvent peak is suitable for use as an internal standard to mitigate this error. Our analysis indicates that this comparatively large error arises from the fixed tuning and matching of the benchtop spectrometer. It is demonstrated that measurements using the PULCON method cannot achieve an average error in quantification of <4% with the benchtop NMR tested here unless the standard and analyte are very similar. Specifically, it focuses on the measurement of aqueous samples with analyte concentrations ranging from 30 mM to 1.7 M and electrical conductivity of up to 84 mS cm - 1 using a 43 MHz instrument. This paper investigates the use of benchtop NMR spectrometers for quantitative analysis with external standards. ![]()
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